Description

L-Ornithinamide, N-[[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- is a sophisticated, multi-functional chemical building block designed for advanced synthetic applications. This compound is engineered to provide a versatile platform for bioconjugation and targeted drug delivery systems, offering precise reactivity and linkage capabilities. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and complex biomolecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of targeted drug conjugates, including Antibody-Drug Conjugates (ADCs) and peptide-drug conjugates.
• Bioconjugation Reagent: Used for site-specific labeling and modification of proteins, antibodies, and peptides via its reactive maleimide and activated carbonate ester groups.
• Proteomics Research: Employed in the development of affinity probes, activity-based probes (ABPs), and other tools for studying enzyme function and protein interactions.
• Linker Chemistry: Serves as a cleavable or non-cleavable linker in the design of prodrugs and controlled-release formulations.
• Diagnostic Agent Synthesis: A key component in creating contrast agents and molecular imaging probes for diagnostic applications.
• Chemical Biology Tool: Facilitates the study of cellular pathways and target engagement through its ability to introduce specific functional groups into biomolecules.

Basic Information

Product Name	L-Ornithinamide, N-[[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
CAS No.	1345681-52-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide; Maleimide-PEG2-Val-Cit-PAB-PNP carbonate; Valine-Citrulline-PAB-PNP Carbonate Maleimide-PEG2; ADC Linker Maleimide-PEG2-VC-PAB-PNP; PNP Carbonate Maleimide-PEG2-Val-Cit-PAB; VC-PAB-PNP Carbonate Maleimide-PEG2; Cleavable ADC Linker with Maleimide and PNP Carbonate; 4-Nitrophenyl Carbonate Maleimide-PEG2-Val-Cit-PAB.
EINECS	Contact for details

Quality Control

Our L-Ornithinamide derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity suitable for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. Store in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.