Description

7H-Pyrrolo[2,3-d]pyrimidine-5-methanol, 4-chloro-7-[2-deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-erythro-pentofuranosyl]-2-[[(1,1-dimethylethyl)dimethylsilyl]amino]- is a sophisticated, multi-protected nucleoside analog intermediate of significant importance in modern pharmaceutical research and development. Its complex structure, featuring tert-butyldimethylsilyl (TBDMS) protecting groups, makes it a critical building block for the synthesis of novel therapeutic agents. This high-purity compound is essential for research organizations and manufacturers focused on nucleoside-based drug discovery, particularly in antiviral and anticancer fields.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of modified nucleosides and nucleotides for potential antiviral and anticancer drugs.
• Antiviral Drug Research: Used in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds targeting viral polymerases.
• Oncology Research: Serves as a building block for creating nucleoside analogs designed to inhibit cancer cell proliferation.
• Pro-drug Synthesis: Employed in the development of pro-drug forms of active nucleoside agents to improve bioavailability and pharmacokinetics.
• Chemical Biology: Used as a tool compound to study nucleic acid metabolism and enzyme mechanisms.
• Process Chemistry Development: Acts as a critical intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7H-Pyrrolo[2,3-d]pyrimidine-5-methanol, 4-chloro-7-[2-deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-erythro-pentofuranosyl]-2-[[(1,1-dimethylethyl)dimethylsilyl]amino]-
CAS No.	1200461-84-2
Molecular Formula	C31H57ClN4O4Si3
Molecular Weight	681.52 g/mol
Synonyms	4-Chloro-7-(2-deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-erythro-pentofuranosyl)-2-[[(1,1-dimethylethyl)dimethylsilyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-methanol; 4-Chloro-2-((tert-butyldimethylsilyl)amino)-7-(2-deoxy-3,5-bis-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-methanol; TBDMS-protected nucleoside analog intermediate; 4-Chloro-7-(2-deoxy-3,5-di-O-TBDMS-β-D-erythro-pentofuranosyl)-2-(N-TBDMS-amino)-7H-pyrrolo[2,3-d]pyrimidine-5-methanol; CAS 1200461-84-2; Protected pyrrolopyrimidine nucleoside.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry to confirm identity, purity, and the integrity of the protecting groups. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent degradation due to its moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.