Description

(S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate is a sophisticated chiral intermediate featuring a complex molecular architecture with multiple stereocenters and functional groups. This compound is of critical importance in the research and development of novel active pharmaceutical ingredients (APIs), particularly in the fields of oncology and antiviral therapeutics. Pharmaceutical R&D teams and fine chemical manufacturers require this high-purity building block for the synthesis of targeted, potent drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel small-molecule drug candidates.
• Oncology Research: Used in the development of targeted kinase inhibitors and other anticancer agents.
• Antiviral Drug Development: Serves as a precursor in the synthesis of compounds targeting viral replication mechanisms.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Asymmetric Synthesis: Acts as a valuable substrate for studying and developing new chiral synthesis methodologies.

Basic Information

Product Name	(S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate
CAS No.	1125828-44-5
Molecular Formula	C32H32ClF3N6O5
Molecular Weight	673.09 g/mol
Synonyms	Ethyl (2S)-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate; BOC-Dap(Bzh)-OEt derivative; Advanced Pyrimidine Intermediate; Chiral Trifluoroethoxy Pyrimidine Ester; Pharmaceutical Building Block 1125828-44-5
EINECS	Contact for details

Quality Control

Our (S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-but-butoxycarbonylaMino)propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and LC-MS for identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.