Description

3-quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-7-[3-[3-[[1-(6-amino-3,5-difluoro-2-pyridinyl)-3-carboxy-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl]amino]-2-hydroxypropoxy]-1-azetidinyl]-8- is a complex, high-purity advanced pharmaceutical intermediate. This compound is of significant value for its role in the synthesis of novel, potent antibacterial agents, specifically targeting DNA gyrase and topoisomerase IV enzymes. It is primarily required by research institutions and pharmaceutical companies engaged in the development of next-generation fluoroquinolone antibiotics.

Application

• Key Intermediate for Novel Antibiotics: Serves as a critical building block in the synthesis of advanced fluoroquinolone-class antibacterial agents.
• Pharmaceutical R&D: Used in medicinal chemistry research for developing new drug candidates with improved efficacy against resistant bacterial strains.
• Process Chemistry & Scale-up: Employed in optimizing synthetic routes and scaling up production for clinical trial material.
• Biochemical Research: Utilized in studies investigating the mechanism of action of topoisomerase inhibitors.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in drug development.

Basic Information

Product Name	3-quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-7-[3-[3-[[1-(6-amino-3,5-difluoro-2-pyridinyl)-3-carboxy-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl]amino]-2-hydroxypropoxy]-1-azetidinyl]-8-
CAS No.	1093185-35-3
Molecular Formula	C38H28ClF4N9O8
Molecular Weight	849.13 g/mol
Synonyms	1-(6-Amino-3,5-difluoropyridin-2-yl)-7-[3-[3-[[1-(6-amino-3,5-difluoropyridin-2-yl)-3-carboxy-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl]amino]-2-hydroxypropoxy]azetidin-1-yl]-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK2140944 Intermediate; Besifloxacin Intermediate Derivative; Advanced Fluoroquinolone Intermediate; DNA Gyrase Inhibitor Intermediate; Topoisomerase IV Inhibitor Precursor; 7-(3-{3-[(1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-3-carboxy-4-oxo-1,4-dihydroquinolin-7-yl)amino]-2-hydroxypropoxy}azetidin-1-yl)-1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict GMP (Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive battery of analytical tests including HPLC for purity and impurity profiling, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.