Description

3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the development of modern fluoroquinolone antibiotics, valued for its precise molecular structure which imparts critical antibacterial properties. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis companies engaged in the production of next-generation antimicrobial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A critical building block in the multi-step synthesis of novel fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new antibacterial drug candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial-scale production of antibiotic APIs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance testing in pharmaceutical manufacturing.
• Chemical Intermediate: Employed in further chemical transformations to create derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-
CAS No.	101987-76-2
Molecular Formula	C18H19ClFN3O3
Molecular Weight	379.82 g/mol
Synonyms	8-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-chloro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; (RS)-Gatifloxacin Carboxylic Acid Intermediate; 3-Quinolinecarboxylic acid, 1,4-dihydro-8-chloro-1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-4-oxo-
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo- is manufactured under strict quality management systems suitable for pharmaceutical applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark place to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.