Description

6,8-Difluoro-1,4-Dihydro-1-(Methylamino)-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid Sulfate is a high-purity, non-steroidal quinolone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or active pharmaceutical ingredient (API) precursor for novel antibacterial agents, leveraging its complex fluorinated quinolone core structure. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced fluoroquinolone antibiotic APIs.
• Antibacterial Research: Core scaffold for investigating new antibacterial agents targeting DNA gyrase and topoisomerase IV.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of quinolone-based drugs.
• Academic & Institutional R&D: Serves as a substrate for studying structure-activity relationships (SAR) and mechanism of action in microbiology and medicinal chemistry.

Basic Information

Product Name	6,8-Difluoro-1,4-Dihydro-1-(Methylamino)-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid Sulfate
CAS No.	100276-37-7
Molecular Formula	C16H19F2N4O4 • H2SO4
Molecular Weight	482.43 g/mol (for the sulfate salt)
Synonyms	6,8-Difluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid sulfate salt; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid sulfate (related derivative); Quinolone carboxylic acid sulfate derivative; Fluoroquinolone intermediate sulfate; AM-1155 sulfate (potential research code); PD 161148 sulfate (potential research code); 3-Quinolinecarboxylic acid, 6,8-difluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-, sulfate (1:1)
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-1,4-Dihydro-1-(Methylamino)-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation via IR and NMR, and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Sulfate Content (Titration)	18.5% - 21.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.