Description

8-Demethoxy-8-Fluoro Gatifloxacin is a key pharmaceutical intermediate in the synthesis of advanced fluoroquinolone antibiotics. This compound is valued for its role in developing potent antibacterial agents with broad-spectrum activity. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antibiotic therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Gatifloxacin and its structural analogs.
• Antibiotic Research & Development: Used in medicinal chemistry for creating and testing novel fluoroquinolone derivatives.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a precursor in the commercial-scale production of antibiotic APIs.
• Chemical Synthesis Studies: Employed in academic and industrial labs to study structure-activity relationships (SAR) in quinolone antibiotics.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control in pharmaceutical processes.

Basic Information

Product Name	8-Demethoxy-8-Fluoro Gatifloxacin
CAS No.	103460-89-5
Molecular Formula	C19H21FN4O4
Molecular Weight	388.39 g/mol
Synonyms	8-Fluoro-8-demethoxy Gatifloxacin; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Derivative; Gatifloxacin Impurity; Gatifloxacin Intermediate; AM-1155 Intermediate; (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our 8-Demethoxy-8-Fluoro Gatifloxacin is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) are provided with each batch, detailing specifications and test results. We adhere to cGMP standards suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.