Description

5-{[(2S,5R)-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazin-1-yl]carbonyl}-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine is a sophisticated heterocyclic compound designed for advanced pharmaceutical research and development. This high-purity chemical intermediate is critical for medicinal chemists exploring novel therapeutic pathways, particularly in oncology and targeted disease modulation. It is primarily utilized by R&D laboratories and pharmaceutical manufacturers engaged in the synthesis of complex small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, high-potency active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Oncology Drug Discovery: Serves as a core structural motif in the development of targeted cancer therapies, including kinase inhibitors.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Biochemical Probe Development: Employed in creating specialized tools for investigating specific biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the biopharma industry.

Basic Information

Product Name	5-{[(2S,5R)-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazin-1-yl]carbonyl}-N-(5-fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine
CAS No.	1046787-18-1
Molecular Formula	C28H39FN8O2
Molecular Weight	538.66 g/mol
Synonyms	5-[(2S,5R)-2,5-Dimethyl-4-[(tetrahydro-2H-pyran-4-yl)methyl]-1-piperazinyl]carbonyl-N-(5-fluoro-2-methyl-4-pyrimidinyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine; (2S,5R)-N-(5-Fluoro-2-methylpyrimidin-4-yl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-2,5-dimethyl-4-(tetrahydro-2H-pyran-4-ylmethyl)piperazine-1-carboxamide; CAS 1046787-18-1; 1046787-18-1; Pyrrolopyrazole-piperazine derivative; Fluoromethylpyrimidine-pyrrolopyrazole conjugate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and LC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.