Description

L-Threonine, O-[3,4-di-O-acetyl-2-(acetylamino)-6-O-(N-acetyl-4,7,8,9-tetra-O-acetyl-1-methyl-α-neuraminosyl)-2-deoxy-α-D-galactopyranosyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- is a sophisticated, fully protected sialyl-T antigen building block, a key intermediate in the chemical synthesis of complex glycopeptides and glycoconjugates. This compound is essential for researchers and manufacturers requiring high-purity, structurally defined intermediates to construct biologically relevant carbohydrate structures with precise stereochemistry. It is primarily utilized in advanced pharmaceutical research, glycobiology studies, and the development of novel therapeutics, including cancer vaccines and targeted drug delivery systems.

Application

• Glycopeptide Synthesis: A critical building block for the solid-phase or solution-phase synthesis of tumor-associated carbohydrate antigens (TACAs) like sialyl-Tn.
• Pharmaceutical R&D: Used in the development of carbohydrate-based vaccines, anticancer agents, and diagnostic tools.
• Glycobiology Research: Enables the study of carbohydrate-protein interactions, cell signaling, and immune response mechanisms.
• Bioconjugation: Serves as a precursor for creating well-defined glycoconjugates for targeted therapy and imaging.
• Process Development: Used in scaling up the production of complex oligosaccharides for clinical trial materials.
• Standards and Reagents: Acts as a high-purity reference standard for analytical method development and quality control.

Basic Information

Item	Details
Product Name	L-Threonine, O-[3,4-di-O-acetyl-2-(acetylamino)-6-O-(N-acetyl-4,7,8,9-tetra-O-acetyl-1-methyl-α-neuraminosyl)-2-deoxy-α-D-galactopyranosyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
CAS No.	189561-77-1
Molecular Formula	C55H71N3O26
Molecular Weight	1182.16 g/mol
Synonyms	Fmoc-Sialyl-Tn Antigen; Fmoc-Thr(Ac3Neu5Acα2-6GalNAcα)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[3,4-di-O-acetyl-2-(acetylamino)-6-O-(N-acetyl-4,7,8,9-tetra-O-acetyl-1-methyl-α-neuraminosyl)-2-deoxy-α-D-galactopyranosyl]-L-threonine; Sialyl Tn Antigen Fmoc Derivative; Fmoc-α-Neu5Ac-(2→6)-α-D-GalNAc-Thr; Glycosylated Amino Acid Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and structural integrity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and correct stereochemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.