Description

5-[3(R)-[[(2(R)-trans-Methyl-1,1-dioxotetrahydro-3(S)-thienyloxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(1,1-dimethylethyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide is a high-purity, complex organic intermediate of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of complex, stereochemically defined molecules for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for the synthesis of complex target molecules, especially those containing fused heterocyclic and thioether functionalities.
• Process Chemistry & Scale-up: Serves as a critical starting material or intermediate in the optimization and pilot-scale synthesis of candidate drugs.
• Stereoselective Synthesis: Valued for its defined stereochemistry (R and S configurations) in constructing molecules with specific three-dimensional orientations crucial for biological activity.
• Reference Standard: Can be utilized as an analytical reference standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-[3(R)-[[(2(R)-trans-Methyl-1,1-dioxotetrahydro-3(S)-thienyloxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(1,1-dimethylethyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide
CAS No.	169273-55-6
Molecular Formula	C27H39N3O5S3
Molecular Weight	597.80 g/mol
Synonyms	(3R,6R)-5-[(2R,3R)-3-[[(2R,3S)-3-Methyl-1,1-dioxo-2-tetrahydrothiophen-2-yl]oxycarbonylamino]-2-hydroxy-4-phenylsulfanylbutyl]-N-tert-butyl-3,4,5,6,7,8-hexahydrothieno[3,2-c]azepine-6-carboxamide; 5-[3(R)-[[(2(R)-trans-Methyl-1,1-dioxotetrahydro-3(S)-thienyloxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(tert-butyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide; CAS 169273-55-6; tert-Butyl (3R,6R)-5-[(2R,3R)-3-[[(2R,3S)-3-methyl-1,1-dioxo-2-tetrahydrothiophen-2-yl]oxycarbonylamino]-2-hydroxy-4-phenylsulfanylbutyl]-3,4,5,6,7,8-hexahydrothieno[3,2-c]azepine-6-carboxylate (related ester form).
EINECS	Contact for details

Quality Control

Our 5-[3(R)-[[(2(R)-trans-Methyl-1,1-dioxotetrahydro-3(S)-thienyloxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(1,1-dimethylethyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.