Description

Hirudin Hv1 CAS NO 101753-64-4 is a highly specific and potent direct thrombin inhibitor, a recombinant protein derived from the medicinal leech. This compound is critical for research and development in the fields of hematology and cardiovascular medicine due to its ability to precisely modulate blood coagulation pathways. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic researchers focused on thrombosis, hemostasis, and novel anticoagulant therapies.

Application

• Pharmaceutical Research & Development: As a reference standard and active component in the development of novel anticoagulant and antithrombotic drugs.
• Biochemical Assay Development: Used as a specific inhibitor in enzymatic assays to study thrombin activity and function in complex biological samples.
• Diagnostic Kit Manufacturing: Incorporated into in-vitro diagnostic (IVD) kits and reagents for the accurate measurement of thrombin levels and coagulation parameters.
• Academic & Biomedical Research: Fundamental tool for investigating the mechanisms of blood clotting, platelet aggregation, and vascular biology.
• Biomaterial Coating: Applied to surface-modify medical devices (e.g., stents, catheters) to create thromboresistant, biocompatible surfaces.
• Quality Control & Standardization: Serves as a calibration standard for ensuring the accuracy and consistency of coagulation testing in clinical laboratories.

Basic Information

Product Name	Hirudin Hv1
CAS No.	101753-64-4
Molecular Formula	C181H263N49O55
Molecular Weight	Approx. 6963.5 g/mol
Synonyms	Recombinant Hirudin Variant 1; Hirudin HV1; r-Hirudin; HV1; Thrombin Inhibitor (Hirudin); Lepirudin (related analogue); Anticoagulant Protein from Hirudo medicinalis; Direct Thrombin Inhibitor (DTI) Hv1
EINECS	Contact for details

Quality Control

Our Hirudin Hv1 is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to a comprehensive battery of analytical tests, including HPLC for purity, peptide mapping for sequence confirmation, and functional activity assays. Certificates of Analysis (COA) detailing purity, potency, endotoxin levels, and sterility (where applicable) are provided to support research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Potency (Thrombin Inhibition Assay)	≥ 15,000 ATU/mg
Water Content (Karl Fischer)	≤ 5.0%
Endotoxin	< 10 EU/mg
Peptide Mapping	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.