Description

Alteplase CAS NO 105857-23-6 is a recombinant tissue plasminogen activator (rt-PA), a thrombolytic agent of critical importance in modern medicine. This biopharmaceutical is engineered to dissolve dangerous blood clots that cause life-threatening conditions such as acute ischemic stroke and myocardial infarction. It is an essential therapeutic for hospitals, emergency care units, and pharmaceutical manufacturers engaged in the production of advanced cardiovascular and cerebrovascular treatments.

Application

• Acute Ischemic Stroke Treatment: The primary clinical application for dissolving clots in cerebral arteries to restore blood flow and minimize brain damage.
• Acute Myocardial Infarction (Heart Attack) Management: Used for the emergency thrombolysis of coronary artery blockages.
• Pulmonary Embolism Thrombolysis: Employed in the treatment of major pulmonary embolisms causing cardiovascular instability.
• Pharmaceutical Active Ingredient: Serves as the key active pharmaceutical ingredient (API) in the formulation of injectable thrombolytic drugs.
• Biomedical Research: Used in research laboratories studying fibrinolysis, thrombosis models, and the development of next-generation thrombolytic agents.

Basic Information

Product Name	Alteplase
CAS No.	105857-23-6
Molecular Formula	C₂₅₆₉H₃₉₈₈N₇₈₀O₇₉₇S₄₀
Molecular Weight	~59,050 Da (Glycosylated form)
Synonyms	Recombinant Tissue Plasminogen Activator; rt-PA; Activase®; Actilyse®; Tissue-Type Plasminogen Activator; t-PA; Plasminogen Activator, Tissue-Type, Recombinant; Alteplase Recombinant
EINECS	Contact for details

Quality Control

Our Alteplase is manufactured and controlled under strict quality systems. It is produced in compliance with current Good Manufacturing Practice (cGMP) guidelines for active pharmaceutical ingredients (APIs). Each batch undergoes comprehensive analytical testing, including potency, purity, and identity assays, to ensure it meets stringent pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, refer to the specific stability data provided in the technical data sheet.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE / SEC-HPLC)	≥ 98.0%
Potency (Clot Lysis Assay)	580,000 – 720,000 IU/mg
Protein Content	≥ 90.0%
Single-Chain Content (HPLC)	≥ 80.0%
pH (in solution)	6.5 – 7.5
Endotoxin	< 2.0 EU/mg
Sterility	Sterile (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.