Description

Dabigatran CAS NO 211914-51-1 is a potent, competitive, and reversible direct thrombin inhibitor. This compound is of paramount importance as the active pharmaceutical ingredient (API) in anticoagulant medications used to prevent and treat thromboembolic disorders. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of novel oral anticoagulants (NOACs) for conditions such as stroke prevention in atrial fibrillation and the treatment of deep vein thrombosis.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms (e.g., capsules) for anticoagulation therapy.
• Reference Standard: Serves as a high-purity chemical standard for quality control and analytical method development in pharmaceutical laboratories.
• Biomedical Research: Used in in vitro and in vivo studies to investigate mechanisms of blood coagulation, thrombosis, and hemostasis.
• Drug Discovery & Development: A key intermediate or target molecule for synthesizing novel thrombin inhibitors and prodrugs like dabigatran etexilate.
• Formulation Development: Employed in R&D for optimizing drug delivery systems, stability studies, and bioavailability enhancement of anticoagulant products.

Basic Information

Product Name	Dabigatran
CAS No.	211914-51-1
Molecular Formula	C25H25N7O3
Molecular Weight	471.51 g/mol
Synonyms	BIBR 953; Dabigatran free base; BIBR-953; BIBR 953ZW; 3-[[2-[[4-(Hexyloxycarbonylamino-iminomethyl)phenylamino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl-(2-pyridyl)amino]propionic acid; Ethyl N-[2-[[[4-[[[(hexylamino)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alaninate (non-prodrug form); Direct Thrombin Inhibitor BIBR 953.
EINECS	Contact for details

Quality Control

Our Dabigatran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Specifications typically align with pharmacopeial expectations for APIs. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.