Description

6-Hydroxywarfarin is a key hydroxylated metabolite of the anticoagulant drug warfarin. This compound is of significant importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the mechanisms of anticoagulant therapy. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and life science industries, enabling precise analytical work and the development of new therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of warfarin and its metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance of warfarin in preclinical and clinical research.
• Biochemical Research: Employed in enzymatic studies to understand the activity of cytochrome P450 enzymes, particularly CYP2C9, involved in warfarin metabolism.
• Analytical Method Development: Serves as a critical calibrant for developing and validating robust analytical methods in quality control laboratories.
• Impurity Profiling: Used to identify and quantify related substances in warfarin active pharmaceutical ingredient (API) manufacturing to ensure product purity and safety.
• Toxicological Studies: Applied in research to assess the toxicity and safety profile of warfarin metabolites.

Basic Information

Product Name	6-Hydroxywarfarin
CAS No.	17834-02-5
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	6-Hydroxywarfarin; 6-Hydroxy-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 6-hydroxy-; Warfarin, 6-hydroxy-; 6-OH-Warfarin; 6-Hydroxy-4-hydroxycoumarin derivative
EINECS	Contact for details

Quality Control

Our 6-Hydroxywarfarin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by validated methods (e.g., HPLC, NMR) is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.