Description

Acenocoumarol CAS NO 152-72-7 is a synthetic coumarin derivative and a potent anticoagulant agent that functions as a vitamin K antagonist. This compound is critical for the development and quality control of pharmaceutical products designed to prevent and treat thromboembolic disorders. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories involved in cardiovascular drug development, anticoagulant therapy research, and reference standard production.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of oral anticoagulant medications for stroke prevention, deep vein thrombosis (DVT), and pulmonary embolism.
• Reference Standard: Used as a high-purity calibrant and standard in pharmacopeial testing (USP, EP) and analytical method development for quality control laboratories.
• Biochemical Research: Employed in studies investigating blood coagulation pathways, vitamin K metabolism, and the mechanisms of action of anticoagulant drugs.
• Formulation Development: Serves as a key ingredient in the R&D of new solid dosage forms (tablets, capsules) with optimized bioavailability and stability profiles.

Basic Information

Product Name	Acenocoumarol
CAS No.	152-72-7
Molecular Formula	C19H15NO6
Molecular Weight	353.33 g/mol
Synonyms	Acenocoumarin; Nicoumalone; Sintrom; Sinthrome; 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one; 3-(α-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin; Zotil
EINECS	205-807-1

Quality Control

Our Acenocoumarol is manufactured and tested under a strict quality management system. Each batch is subjected to comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical applications, including identification, assay, and impurity profile analysis. A Certificate of Analysis (COA) detailing the results against relevant pharmacopeial specifications (USP/EP) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.