Description

Efegatran CAS NO 105806-65-3 is a synthetic, low molecular weight thrombin inhibitor, representing a key intermediate in the development of novel anticoagulant and antithrombotic agents. Its precise mechanism of action and high specificity make it a valuable tool compound for pharmaceutical research and development. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular drug discovery, hematology studies, and the synthesis of next-generation therapeutic peptides.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of advanced direct thrombin inhibitors (DTIs) and related anticoagulant APIs.
• Biochemical Research: Used as a selective probe to study thrombin's role in coagulation cascades, inflammation, and cellular signaling pathways.
• In-Vitro Diagnostics: Serves as a reference standard or active component in diagnostic kits for assessing blood clotting disorders and thrombotic risk.
• Medicinal Chemistry: A key scaffold for structure-activity relationship (SAR) studies aimed at optimizing potency, selectivity, and pharmacokinetic properties of antithrombotic drugs.
• Preclinical Development: Employed in animal models to evaluate the efficacy and safety profiles of novel anticoagulant candidates.

Basic Information

Product Name	Efegatran
CAS No.	105806-65-3
Molecular Formula	C23H40N8O7
Molecular Weight	540.62 g/mol
Synonyms	Efegatran; (2R,4R)-4-Methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid; BCH-1056; CRC 220; CRC-220; Thrombin inhibitor BCH 1056; MDL 28,050
EINECS	Contact for details

Quality Control

Our Efegatran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR, MS), and stringent controls for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.