Description

(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-3,5-diamino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2S,3R,4R,5S,6R)-3,4-diamino-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-cyclohexyl]-2-hydroxy-butanamide is a complex, high-purity aminoglycoside derivative with significant biological activity. This compound is valued for its precise stereochemistry and functional group array, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, particularly antibiotics and specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of next-generation aminoglycoside antibiotics and complex therapeutic molecules.
• Biochemical Research: Used as a reference standard or probe in microbiological and enzymatic studies to investigate mechanisms of action and resistance.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs for drug discovery.
• API Development: Acts as a critical precursor in the development and scale-up of Active Pharmaceutical Ingredients (APIs) with specific stereochemical requirements.
• Academic Research: Utilized in university and institutional labs for studying carbohydrate chemistry, synthetic methodology, and molecular recognition.

Basic Information

Product Name	(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-3,5-diamino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2S,3R,4R,5S,6R)-3,4-diamino-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-cyclohexyl]-2-hydroxy-butanamide
CAS No.	161822-04-4
Molecular Formula	C₂₂H₄₆N₈O₁₀
Molecular Weight	582.66 g/mol
Synonyms	Paromamine derivative; 4-Amino-2-hydroxy-N-((1R,2S,3S,4R,5S)-3,5-diamino-4-((2R,3R,6S)-3-amino-6-(aminomethyl)tetrahydro-2H-pyran-2-yl)oxy-2-((2S,3R,4R,5S,6R)-3,4-diamino-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxycyclohexyl)butanamide; Neamine-related intermediate; Complex aminocyclitol glycoside; Antibiotic synthetic precursor
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under strict quality management systems, ensuring identity, purity, and stereochemical integrity. Our standard grade meets specifications suitable for research and pharmaceutical development. Certificates of Analysis (COA) are provided with each shipment, detailing results from advanced analytical techniques including HPLC, NMR, and MS. We support compliance with cGMP and ISO 9001 standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.