Description

Dihydrostreptomycin is a semi-synthetic aminoglycoside antibiotic derived from streptomycin. This compound is valued for its broad-spectrum antibacterial activity, particularly against Gram-negative bacteria, and its role as a key intermediate in pharmaceutical synthesis. It is essential for manufacturers in the pharmaceutical, veterinary medicine, and agricultural sectors requiring a reliable, high-purity antibiotic component.

Application

• Pharmaceutical Intermediate: Serves as a critical starting material or intermediate in the synthesis of advanced antibiotic formulations and combination drugs.
• Veterinary Medicine: Used in the preparation of injectable solutions and premixes for the treatment of bacterial infections in livestock and poultry.
• Agricultural Bactericide: Formulated for use in protecting crops from certain bacterial diseases, though application is highly regulated.
• Microbiological Research: Employed as a selective agent in cell culture media and in laboratory studies of bacterial resistance mechanisms.
• API Manufacturing: Acts as an Active Pharmaceutical Ingredient (API) in the production of specific anti-tuberculosis and other therapeutic agents.

Basic Information

Product Name	Dihydrostreptomycin
CAS No.	128-46-1
Molecular Formula	C21H41N7O12
Molecular Weight	583.59 g/mol
Synonyms	Dihydrostreptomycin sulfate (common salt form); Streptomycin, dihydro-; DHS; 2-[(1S,2R,3R,4S,5R,6S)-5-(diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]guanidine; Antibiotic 130-33; NSC 403169
EINECS	204-886-5

Quality Control

Our Dihydrostreptomycin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting compliance with relevant standards are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 5.0%
pH (1% solution)	4.5 - 7.0
Residue on Ignition	≤ 1.0%
Specific Rotation	-83° to -90° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.