Description

Neomycin Sulfate CAS NO 1405-10-3 is a broad-spectrum aminoglycoside antibiotic complex derived from *Streptomyces fradiae*. This compound is valued for its potent bactericidal activity against a wide range of Gram-negative and some Gram-positive bacteria. It is a critical raw material for the pharmaceutical, veterinary medicine, and research sectors. Its efficacy and stability make it a cornerstone in formulations requiring reliable antimicrobial action.

Application

• Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) in topical preparations such as creams, ointments, and eye/ear drops for treating bacterial infections.
• Veterinary Medicine: Used in medicated feeds, topical solutions, and injectables for the prevention and treatment of bacterial infections in livestock and companion animals.
• Cell Culture & Microbiology Research: Employed as a selective agent in cell culture media to prevent bacterial contamination.
• Combination Therapies: Frequently combined with other antibiotics (e.g., bacitracin, polymyxin B) in over-the-counter first-aid ointments to broaden the spectrum of activity.
• Gut Decontamination: Used orally for preoperative bowel preparation and to suppress intestinal flora in hepatic encephalopathy, though this use is now less common.
• Agricultural Applications: Incorporated into certain agricultural sprays for controlling bacterial plant diseases.

Basic Information

Product Name	Neomycin Sulfate
CAS No.	1405-10-3
Molecular Formula	C23H46N6O13 • xH2SO4
Molecular Weight	~908.9 (for Neomycin B sulfate)
Synonyms	Neomycin Sulphate; Framycetin Sulfate; Mycifradin Sulfate; Neomin; Bykomycin; Vonamycin Powder V; Neomycin B Sulfate; O-2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine Sulfate
EINECS	215-773-1

Quality Control

Our Neomycin Sulfate is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality is assured through a rigorous battery of tests including identification, potency (assay), and impurity profiling. We can supply material compliant with USP, EP, BP, and JP monographs. A comprehensive Certificate of Analysis (COA) documenting purity, residual solvents, and microbiological data is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a low-humidity environment to prevent degradation and clumping.

Specification

Item	Specification
Description	White or almost white powder, hygroscopic
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
pH (1% Solution)	5.0 - 7.5
Assay (Anhydrous Basis)	Not less than 680 µg/mg (as Neomycin)
Loss on Drying	Not more than 8.0%
Sulfate Content	17.0% - 21.0%
Related Substances (HPLC)	Individual impurity: Not more than 2.0% Total impurities: Not more than 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	<0.25 IU/mg (if for parenteral use)
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.