Description

Isepamicin Sulfate is a semi-synthetic aminoglycoside antibiotic derived from gentamicin B, offering a broad spectrum of activity against Gram-negative and some Gram-positive bacteria. Its primary value lies in its enhanced stability against many bacterial aminoglycoside-modifying enzymes, making it a critical agent for research into combating resistant strains. This compound is essential for pharmaceutical R&D, analytical reference standards, and the development of novel antibacterial formulations.

Application

• Pharmaceutical research and development of new antibacterial agents.
• Manufacturing of high-purity active pharmaceutical ingredients (APIs) for injectable formulations.
• Use as an analytical reference standard for quality control and regulatory compliance testing.
• Biochemical research to study bacterial resistance mechanisms and aminoglycoside pharmacology.
• Preparation of laboratory-grade reagents for microbiological studies.
• Development of combination therapies for severe systemic infections.

Basic Information

Product Name	Isepamicin Sulfate
CAS No.	67814-76-0
Molecular Formula	C22H43N5O12 • xH2SO4
Molecular Weight	569.60 g/mol (for free base)
Synonyms	Isepamicin Sulphate; Sch 21420; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-gentamicin B Sulfate; Antibiotic Sch 21420; (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2R,3S,4R,5R)-5-(aminomethyl)-3,4-dihydroxyoxolan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide sulfate
EINECS	Contact for details

Quality Control

Our Isepamicin Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and stringent limits for related substances, residual solvents, and bacterial endotoxins. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications developed for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC, anhydrous basis)	≥ 95.0%
Water Content (KF)	≤ 10.0 %
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH limits
pH (1% solution)	3.5 - 5.5
Specific Rotation	+100° to +120°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.