Description

Neomycin CAS NO 1404-04-2 is a broad-spectrum aminoglycoside antibiotic complex, primarily consisting of Neomycin B. This compound is valued for its potent bactericidal activity against a wide range of Gram-negative and some Gram-positive bacteria. It is a critical active pharmaceutical ingredient (API) essential for manufacturers in the pharmaceutical, veterinary medicine, and research sectors. Its efficacy and established safety profile make it a cornerstone in topical and oral anti-infective formulations.

Application

• Pharmaceutical API: Primary use as an active ingredient in topical creams, ointments, eye/ear drops, and oral tablets for treating bacterial infections.
• Veterinary Medicine: Key component in medicated feeds, topical treatments, and injectables for livestock, poultry, and companion animals.
• Cell Culture Research: Used in microbiology and cell biology laboratories as a selective agent to prevent bacterial contamination.
• Combination Therapies: Formulated with other antibiotics (e.g., bacitracin, polymyxin B) in over-the-counter first-aid ointments for enhanced spectrum.
• Gastrointestinal Preparations: Employed in oral solutions for preoperative bowel sterilization and hepatic coma management.
• Agricultural Applications: Limited use in plant pathology for controlling specific bacterial diseases in high-value crops.

Basic Information

Product Name	Neomycin
CAS No.	1404-04-2
Molecular Formula	C23H46N6O13 (Neomycin B)
Molecular Weight	614.64 g/mol (Neomycin B)
Synonyms	Neomycin Sulfate; Neomycin B; Fradiomycin; Mycifradin; Neomin; Framycetin; O-2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine; Vonamycin Powder V
EINECS	215-773-1

Quality Control

Our Neomycin is manufactured under strict quality management systems, with grades available to meet USP, EP, BP, and JP pharmacopeial standards. Every batch undergoes comprehensive analytical testing, including identification, potency (assay), impurity profiling, and specific tests for related substances. A Certificate of Analysis (COA) documenting purity, residual solvents, and microbiological data is provided to ensure compliance with your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥ 680 µg/mg (as Neomycin B)
pH (10% solution)	5.0 - 7.5
Loss on Drying	≤ 8.0 %
Residue on Ignition	≤ 1.0 %
Related Substances (HPLC)	Individual impurity ≤ 2.0% Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.