Description

Nebramycin CAS NO 11048-13-8 is a complex of aminoglycoside antibiotics, primarily composed of tobramycin and other related compounds, known for its potent broad-spectrum antibacterial activity. This product is critical for pharmaceutical manufacturers requiring a reliable and high-purity active pharmaceutical ingredient (API) for the formulation of injectable and ophthalmic solutions. It is essential for producers targeting serious infections, particularly those caused by Gram-negative bacteria such as *Pseudomonas aeruginosa*. Key industries that depend on this compound include the pharmaceutical sector for human and veterinary medicine, as well as research institutions involved in antimicrobial development.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable antibiotic formulations for systemic infections.
• Ophthalmic Preparations: Key component in eye drops and ointments for treating bacterial conjunctivitis and keratitis.
• Veterinary Medicine: Used in treatments for bacterial infections in livestock and companion animals.
• Research & Development: Serves as a standard or investigational compound in microbiological and pharmacological studies.
• Combination Therapies: Utilized in synergistic antibiotic combinations to combat resistant bacterial strains.
• Manufacturing of Intermediates: Acts as a starting material for the synthesis of specialized antibiotic derivatives.

Basic Information

Product Name	Nebramycin
CAS No.	11048-13-8
Molecular Formula	C18H37N5O9 (for Tobramycin, main component)
Molecular Weight	467.52 g/mol (for Tobramycin)
Synonyms	Tobramycin Complex; Nebramycin Factor 6; Tenebrimycin; Tobracin; TOBI; Obramycin; 3'-Deoxykanamycin B; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
EINECS	234-279-7

Quality Control

Our Nebramycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Specifications are aligned with major pharmacopoeial guidelines, including USP and EP monographs. A detailed Certificate of Analysis (COA), providing results for identity, potency, purity, and related substances, is supplied with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
pH (1% solution)	9.0 - 11.0
Water Content (KF)	≤ 8.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Bacterial Endotoxins	< 1.0 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.