Description

2,2-Dimethyl-propionic acid (6ar,10ar)-1-(tert-butyl-dimethyl-silanyloxy)-3-(1,1-dimethyl-heptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-9-ylmethyl ester is a high-purity, complex organic ester derivative featuring a protected hydroxyl group and a sterically hindered carboxylic acid moiety. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its specific stereochemistry and functional groups, which are essential for constructing sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of novel therapeutic agents, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) or anti-inflammatory pathways.
• Organic Synthesis Research: Serves as a versatile precursor in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for drug discovery.
• Chiral Chemistry Studies: Used in the development and optimization of asymmetric synthesis routes due to its defined stereocenters at the 6aR and 10aR positions.
• Process Chemistry Development: Employed in scale-up studies and route scouting for the efficient and cost-effective production of target molecules.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	2,2-Dimethyl-propionic acid (6ar,10ar)-1-(tert-butyl-dimethyl-silanyloxy)-3-(1,1-dimethyl-heptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-9-ylmethyl ester
CAS No.	137945-54-1
Molecular Formula	C₃₄H₅₈O₄Si
Molecular Weight	558.91 g/mol
Synonyms	Pivalic acid, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-yl ester, (6aR,10aR)-rel-; HU-243; 1,1-Dimethylethyl[[(6aR,10aR)-3-(1,1-dimethylheptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran-9-yl]oxy]dimethylsilane-9-carboxylic acid, 9-pivalate; (6aR,10aR)-9-[(tert-Butyldimethylsilyl)oxy]-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6-dimethyl-6H-benzo[c]chromene-9-carboxylic acid pivalic ester; HU 243 tert-butyldimethylsilyl ether; A cannabinoid synthetic intermediate.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity essential for sensitive pharmaceutical applications. All material is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.