Description

(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) H-Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2 is a synthetic peptide analog of parathyroid hormone-related protein (PTHrP) designed for advanced biochemical and pharmacological research. This compound is a critical tool for studying bone metabolism, calcium homeostasis, and the role of PTHrP in cancer biology due to its specific antagonistic properties. It is essential for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on metabolic disorders and oncology.

Application

• Biochemical Research: Used as a selective antagonist to study PTH/PTHrP receptor signaling pathways and interactions.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of therapeutics for hypercalcemia of malignancy and osteoporosis.
• In Vitro & In Vivo Studies: Employed in cell-based assays and animal models (human, mouse, rat) to investigate bone biology and calcium regulation.
• Receptor Binding Assays: Utilized to characterize and quantify binding affinity to PTH1 receptors in competitive binding experiments.
• Signal Transduction Research: A key reagent for elucidating downstream effects of PTHrP antagonism on cAMP and other second messenger systems.
• Academic & Institutional Research: Supports fundamental research in endocrinology, oncology, and skeletal physiology.

Basic Information

Item	Details
Product Name	(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) H-Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2
CAS No.	129622-68-0
Molecular Formula	C173H280N58O48
Molecular Weight	3975.4 g/mol
Synonyms	(Asn10,Leu11,D-Trp12)-PTHrP(7-34) amide; PTHrP (7-34) amide, (Asn10,Leu11,D-Trp12)-; [Asn10,Leu11,D-Trp12]PTHrP(7-34)NH2; Parathyroid Hormone-Related Protein (7-34) amide analog; PTHrP antagonist (7-34); hPTHrP(7-34)NH2 analog; [D-Trp12]PTHrP(7-34) amide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality systems. Each batch of (Asn10,Leu11,D-Trp12)-pTHrP(7-34) amide undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated at -20°C. Allow the vial to warm to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
Acetate Content (HPIC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.