Description

2-(3,5-Difluoro-Phenyl)-Pyrimidine-5-Carbonitrile is a high-purity, functionalized heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular architecture, featuring both a pyrimidine core and a difluorophenyl moiety, which is essential for modulating the physicochemical and biological properties of target molecules. This intermediate is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and CNS disorders.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient pyrimidine ring.
• Chemical Biology Probes: Serves as a core structure for developing fluorescent tags or enzyme inhibitors used in biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific complex molecules.

Basic Information

Product Name	2-(3,5-Difluoro-Phenyl)-Pyrimidine-5-Carbonitrile
CAS No.	960198-64-5
Molecular Formula	C11H5F2N3
Molecular Weight	217.18 g/mol
Synonyms	2-(3,5-Difluorophenyl)pyrimidine-5-carbonitrile; 5-Cyano-2-(3,5-difluorophenyl)pyrimidine; 2-(3,5-Difluorophenyl)-5-pyrimidinecarbonitrile; Pyrimidine-5-carbonitrile, 2-(3,5-difluorophenyl)-; 960198-64-5; 2-(3,5-Difluorophenyl)pyrimidine-5-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(3,5-Difluorophenyl)-Pyrimidine-5-Carbonitrile is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced research and development. Our standard quality commitment includes HPLC purity ≥97% (with higher grades available), identity confirmation via spectroscopic methods, and strict control of residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.