Description

2-(2,5-Difluoro-Phenyl)-Pyrimidine-5-Carboxylic Acid Amide is a high-purity, advanced pharmaceutical intermediate characterized by its difluorophenyl-pyrimidine core structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapies. Pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) need this material to develop next-generation small molecule drugs with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Oncology Drug Development: Used in research and production of targeted cancer therapies due to its specific molecular scaffold.
• Chemical Biology Research: Employed as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client pipelines.
• API Manufacturing: Integrated into Good Manufacturing Practice (GMP) processes for the commercial-scale production of approved pharmaceuticals.

Basic Information

Product Name	2-(2,5-Difluoro-Phenyl)-Pyrimidine-5-Carboxylic Acid Amide
CAS No.	960198-58-7
Molecular Formula	C11H7F2N3O
Molecular Weight	235.19 g/mol
Synonyms	2-(2,5-Difluorophenyl)pyrimidine-5-carboxamide; 2-(2,5-Difluorophenyl)-5-pyrimidinecarboxamide; 5-Pyrimidinecarboxamide, 2-(2,5-difluorophenyl)-; 960198-58-7; 2-(2,5-Difluoro-phenyl)-pyrimidine-5-carboxylic acid amide; Amide of 2-(2,5-difluorophenyl)pyrimidine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(2,5-Difluoro-Phenyl)-Pyrimidine-5-Carboxylic Acid Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports development and production needs from research grade to cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this light-sensitive material.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.