Description

2-(2,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid Methyl Ester is a high-value fluorinated pyrimidine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its molecular architecture, featuring a difluorophenyl group and an ester-functionalized pyrimidine ring, makes it indispensable for constructing complex pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the biological activity of the fluorinated pyrimidine scaffold.
• Material Science: Serves as a precursor for specialty chemicals and functional materials requiring specific fluorinated aromatic structures.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the exploration of new chemical spaces in heterocyclic chemistry.

Basic Information

Item	Details
Product Name	2-(2,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid Methyl Ester
CAS No.	960198-53-2
Molecular Formula	C12H8F2N2O2
Molecular Weight	250.20 g/mol
Synonyms	Methyl 2-(2,5-difluorophenyl)pyrimidine-5-carboxylate; 2-(2,5-Difluorophenyl)-5-pyrimidinecarboxylic acid methyl ester; 960198-53-2; 2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid methyl ester; Methyl 2-(2,5-difluorophenyl)-5-pyrimidinecarboxylate
EINECS	Contact for details

Quality Control

Every batch of 2-(2,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid Methyl Ester is produced and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry to confirm identity and quality. A Certificate of Analysis (COA) is supplied with each shipment, and custom purity grades (e.g., >97%, >98%, >99%) are available to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.