Description

(2R)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-4,4-Dimethylpyrrolidine-2-Carboxylic Acid is a high-purity, chiral Fmoc-protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and CROs/CMOs developing novel therapeutic peptides, peptide hormones, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the controlled assembly of peptides using Fmoc chemistry protocols.
• Pharmaceutical Research: Building block for the development of novel peptide-based drugs, including hormone analogs and receptor-targeting therapeutics.
• Peptidomimetic Design: Used to incorporate the constrained 4,4-dimethylpyrrolidine-2-carboxylic acid scaffold into molecules designed to mimic peptide structure and function with enhanced metabolic stability.
• Combinatorial Chemistry Libraries: Enables the creation of diverse, stereochemically defined compound libraries for high-throughput screening in drug discovery.
• Bioconjugation: Can be utilized in the synthesis of peptide tags or linkers for protein labeling and bioconjugation strategies.
• Academic & Industrial R&D: Fundamental reagent for research in medicinal chemistry, chemical biology, and synthetic methodology development.

Basic Information

Item	Details
Product Name	(2R)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-4,4-Dimethylpyrrolidine-2-Carboxylic Acid
CAS No.	960156-21-2
Molecular Formula	C24H25NO5
Molecular Weight	407.46 g/mol
Synonyms	Fmoc-Dmp-OH; Fmoc-(2R)-4,4-dimethylpyrrolidine-2-carboxylic acid; (R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-4,4-dimethylpyrrolidine-2-carboxylic acid; (2R)-1-(9-Fluorenylmethoxycarbonyl)-4,4-dimethylpyrrolidine-2-carboxylic acid; Fmoc-D-4,4-dimethylproline; N-α-Fmoc-4,4-dimethyl-D-proline; N-Fmoc-4,4-dimethyl-D-proline; Fmoc-4,4-dimethyl-D-proline
EINECS	Contact for details

Quality Control

Our (2R)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-4,4-Dimethylpyrrolidine-2-Carboxylic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.