Description

Benzyl (1R*,2R*,3R*,5S*)-2-(Benzyloxycarbonylamino)-6-Oxa-Bicyclo[3.1.0]Hexane-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex, conformationally constrained bicyclic scaffold. This compound is of significant value for medicinal chemistry research and process development, serving as a key chiral building block for the synthesis of novel therapeutic agents. It is primarily sought after by R&D chemists and process scientists in the pharmaceutical and biotechnology industries working on new drug candidates, particularly those targeting central nervous system (CNS) disorders and other areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a building block for constructing novel compound libraries in drug discovery programs, especially for probing new chemical space.
• Process Chemistry Development: Serves as a key intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Asymmetric Synthesis: Utilized in the development of stereoselective synthetic pathways due to its defined stereochemistry at multiple centers.
• Protease Inhibitor Scaffold: The oxa-bicyclo[3.1.0]hexane core is a privileged structure in the design of enzyme inhibitors.
• Academic & Institutional Research: Employed in universities and research institutes for studies in organic synthesis methodology and chemical biology.

Basic Information

Item	Details
Product Name	Benzyl (1R*,2R*,3R*,5S*)-2-(Benzyloxycarbonylamino)-6-Oxa-Bicyclo[3.1.0]Hexane-3-Carboxylate
CAS No.	959745-78-9
Molecular Formula	C21H21NO5
Molecular Weight	367.40 g/mol
Synonyms	Benzyl 2-[(benzyloxy)carbonylamino]-6-oxabicyclo[3.1.0]hexane-3-carboxylate; (1R*,2R*,3R*,5S*)-2-[(Benzyloxycarbonyl)amino]-6-oxabicyclo[3.1.0]hexane-3-carboxylic Acid Benzyl Ester; 6-Oxabicyclo[3.1.0]hexane-3-carboxylic acid, 2-[[(benzyloxy)carbonyl]amino]-, benzyl ester, (1R*,2R*,3R*,5S*)-; Z-Amino-6-oxabicyclo[3.1.0]hexane-3-carboxylic Acid Benzyl Ester (benzyl ester); Cbz-Protected 6-Oxa-bicyclo[3.1.0]hexane Amino Acid Ester.
EINECS	Contact for details

Quality Control

Our Benzyl (1R*,2R*,3R*,5S*)-2-(Benzyloxycarbonylamino)-6-Oxa-Bicyclo[3.1.0]Hexane-3-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.