Description

Fmoc-L-2-Carbamoylphe CAS NO 959583-60-9 is a protected amino acid derivative, specifically an Fmoc-protected phenylalanine analog with a carbamoyl side chain modification. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and peptidomimetics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to study structure-activity relationships (SAR) and enhance metabolic stability or binding affinity.
• Bioconjugation & Probe Development: Used to introduce a carbamoyl-functionalized phenylalanine residue into peptides for subsequent labeling or conjugation with other molecules.
• Combinatorial Chemistry Libraries: Serves as a versatile monomer for generating diverse libraries of peptide-like compounds for high-throughput screening.
• Academic & Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and the development of novel bioactive peptides.

Basic Information

Product Name	Fmoc-L-2-Carbamoylphe
CAS No.	959583-60-9
Molecular Formula	C₂₆H₂₄N₂O₅
Molecular Weight	444.48 g/mol
Synonyms	Fmoc-2-Carbamoyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-carbamoyl-L-phenylalanine; Fmoc-Cpa(2-CONH2)-OH; Fmoc-L-2-Carbamoylphenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[2-(aminocarbonyl)phenyl]propanoic acid; Fmoc-2-CONH2-Phe-OH; Nα-Fmoc-2-carbamoyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Carbamoylphe is manufactured under strict quality control protocols to ensure high chemical purity and consistency, essential for sensitive synthetic applications. Each batch is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.