Description

n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2S,3S)-3-Amino-3-(4-Fluoro-Phenyl)-2-Hydroxypropionic Acid is a sophisticated, optically pure amino acid derivative protected with the Fmoc group. This compound matters as a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D and process development teams for creating active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring fluorinated and conformationally constrained structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and APIs.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative in Fmoc-based SPPS protocols for constructing complex peptide sequences.
• Peptidomimetic Design: Essential for introducing the unique (2S,3S)-3-amino-2-hydroxy acid scaffold with a fluorinated aromatic side chain into drug candidates.
• Medicinal Chemistry Research: Serves as a building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Bioconjugation: Potential use in the synthesis of labeled peptides or peptide-drug conjugates for diagnostic or therapeutic applications.
• Chemical Biology Probes: Utilized in the development of enzyme inhibitors or molecular probes targeting biological systems.

Basic Information

Product Name	n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2S,3S)-3-Amino-3-(4-Fluoro-Phenyl)-2-Hydroxypropionic Acid
CAS No.	959583-03-0
Molecular Formula	C24H20FNO5
Molecular Weight	421.42 g/mol
Synonyms	Fmoc-(2S,3S)-3-Amino-3-(4-fluorophenyl)-2-hydroxypropionic acid; (2S,3S)-Fmoc-AHP(4-F)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(4-fluorophenyl)-D-β-hydroxypropanoic acid; Fmoc-D-3-Amino-3-(4-fluorophenyl)-β-hydroxypropionic acid; Fmoc-(2S,3S)-AHP(4-F)-OH; (2S,3S)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-fluorophenyl)-2-hydroxypropanoic acid; N-Fmoc-3-amino-3-(4-fluorophenyl)-D-β-hydroxypropionic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized to confirm identity, purity, and enantiomeric excess, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing specific results for assay, chiral purity, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.