Description

Boc-(R)-α-(3-Thiophenylmethyl)-Proline is a high-purity, non-natural amino acid derivative featuring a thiophene side chain and a Boc-protected amine. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and bioactive peptides, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, enzyme modulators, and other small-molecule therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate a constrained proline analog with a lipophilic thiophene moiety.
• Chemical Biology Research: Serves as a valuable probe or building block for studying protein-protein interactions and structure-activity relationships (SAR).
• Agrochemical Development: Employed in the research and synthesis of novel active ingredients with potential herbicidal or fungicidal activity.
• Material Science: Investigated as a monomer or precursor for specialty polymers and functional materials.

Basic Information

Product Name	Boc-(R)-α-(3-Thiophenylmethyl)-Proline
CAS No.	959578-37-1
Molecular Formula	C16H21NO4S
Molecular Weight	323.41 g/mol
Synonyms	(R)-1-[(tert-Butoxycarbonyl)-3-(thiophen-3-ylmethyl)-L-proline; tert-Butyl (2R)-2-(3-thienylmethyl)-1-pyrrolidinecarboxylate; Boc-3-(3-Thienyl)-(R)-proline; (R)-N-Boc-3-(3-Thienylmethyl)proline; (R)-1-Boc-3-(thiophen-3-ylmethyl)proline; Boc-(R)-3-(3-Thienylmethyl)proline; (R)-α-(3-Thienylmethyl)-1-Boc-proline
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(3-Thiophenylmethyl)-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% e.e.
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.