Description

Boc-(R)-α-(2-Methylbenzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a chiral 2-methylbenzyl side chain. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and bioactive peptides, where stereochemical integrity is paramount. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of protease inhibitors, enzyme modulators, and other small-molecule drugs.
• Peptide Synthesis: Serves as a protected proline analog for the solid-phase and solution-phase synthesis of constrained peptides and peptidomimetics.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for stereoselective transformations.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the design of molecular probes.
• Agrochemical Development: A potential intermediate in the synthesis of chiral active ingredients for crop protection.
• Material Science: Can be incorporated into specialty polymers and advanced materials requiring specific chiral architectures.

Basic Information

Product Name	Boc-(R)-α-(2-Methylbenzyl)-Proline
CAS No.	959576-64-8
Molecular Formula	C₁₉H₂₇NO₄
Molecular Weight	333.43 g/mol
Synonyms	(R)-1-[(tert-Butoxy)carbonyl]-2-(2-methylbenzyl)pyrrolidine-2-carboxylic acid; (R)-1-Boc-2-(2-methylbenzyl)proline; tert-Butyl (2R)-2-(2-methylbenzyl)pyrrolidine-1,2-dicarboxylate; Boc-(R)-2-(2-Methylbenzyl)proline; (R)-N-Boc-2-(2-Methylbenzyl)proline; (R)-α-(2-Methylbenzyl)-N-Boc-proline; 959576-64-8; (R)-1-Boc-2-(o-methylbenzyl)proline
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(2-Methylbenzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.