Description

n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2S,3S)-3-Amino-2-Hydroxy-3-(3-Methoxy-Phenyl)Propionic Acid is a sophisticated, optically pure Fmoc-protected amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide and peptidomimetic structures, where stereochemical integrity is paramount. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic agents, peptide-based drugs, and diagnostic compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental monomer for the automated synthesis of custom peptides and peptide libraries.
• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted therapies, especially in oncology and metabolic diseases.
• Peptidomimetic Drug Design: Used to incorporate non-natural amino acid motifs into drug candidates to enhance stability, bioavailability, and receptor binding affinity.
• Bioconjugation and Probe Development: Employed in creating labeled peptides for diagnostic imaging, biomarker discovery, and biochemical assay development.
• Academic and Industrial R&D: A vital reagent for medicinal chemistry research, exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Serves as a starting material for scaling up the production of chiral compounds under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	n-(9H-Fluoren-9-Yl)Methoxy]Carbonyl (2S,3S)-3-Amino-2-Hydroxy-3-(3-Methoxy-Phenyl)Propionic Acid
CAS No.	959576-00-2
Molecular Formula	C25H23NO6
Molecular Weight	433.45 g/mol
Synonyms	Fmoc-(2S,3S)-3-Amino-2-hydroxy-3-(3-methoxyphenyl)propionic acid; (2S,3S)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-3-(3-methoxyphenyl)propanoic acid; Fmoc-AHP(3-OMe)-OH; Fmoc-3-Amino-2-hydroxy-3-(3-methoxyphenyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2-hydroxy-3-(3-methoxyphenyl)propanoic acid; (2S,3S)-3-(Fmoc-amino)-2-hydroxy-3-(3-methoxyphenyl)propionic acid; Fmoc-(S,S)-AHMPA; Fmoc-protected β-hydroxy-α-amino acid derivative
EINECS	Contact for details

Quality Control

Our production of this chiral building block adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical purity, and identity confirmation. While not a bulk API, our quality systems are designed to support cGMP for use in pharmaceutical development, and we can provide material suitable for research and non-GMP pilot-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); containers should be opened under a dry atmosphere and resealed immediately after use to prevent degradation. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.