Description

Boc-3-(Fmoc-Aminomethyl)-L-Phenylalanine is a sophisticated, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over side-chain functionality during solid-phase and solution-phase peptide assembly. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of a uniquely functionalized phenylalanine residue with a protected aminomethyl side chain, enabling post-assembly modifications.
• Solution-Phase Peptide Chemistry: Used in convergent synthesis strategies for complex peptides where orthogonal protection (Boc and Fmoc) is essential for sequential deprotection cycles.
• Peptidomimetic Drug Discovery: Serves as a precursor for creating non-natural amino acid scaffolds and constrained peptide structures with enhanced metabolic stability and binding affinity.
• Chemical Biology and Bioconjugation: The reactive aminomethyl group, once deprotected, provides a versatile handle for site-specific labeling, linker attachment, or conjugation with other molecules like fluorophores or drugs.
• Research Scale API Development: Employed in the early-stage research and process development for potential peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Boc-3-(Fmoc-Aminomethyl)-L-Phenylalanine
CAS No.	959573-13-8
Molecular Formula	C31H34N2O6
Molecular Weight	530.62 g/mol
Synonyms	N-α-Boc-N-ε-Fmoc-L-3-(aminomethyl)phenylalanine; Boc-Phe(3-CH2NH-Fmoc)-OH; (2S)-3-[3-[(9H-Fluoren-9-ylmethoxycarbonylamino)methyl]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; Fmoc-3-aminomethyl-L-phenylalanine(Boc)-OH; Boc-L-Phe(3-NHFmoc)-OH; tert-Butyloxycarbonyl-3-(9-fluorenylmethyloxycarbonylaminomethyl)-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-3-(Fmoc-Aminomethyl)-L-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.