Description

(3R)-4-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Thiomorpholine-3-Carboxylic Acid is a sophisticated, chiral thiomorpholine derivative primarily used as a key building block in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity, structurally complex intermediates for pharmaceutical development. It is specifically designed for applications in peptide chemistry and the synthesis of novel active pharmaceutical ingredients (APIs), where its unique stereochemistry and functional groups enable precise molecular construction.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) as a protected amino acid derivative, facilitating the introduction of the thiomorpholine scaffold.
• Chemical Research & Development: Serves as a versatile intermediate in medicinal chemistry for creating compound libraries and exploring structure-activity relationships (SAR).
• Fmoc-Protection Strategy: The 9-fluorenylmethoxycarbonyl (Fmoc) protecting group makes it suitable for standard Fmoc-based peptide synthesis protocols.
• Ligand and Catalyst Synthesis: Potential precursor for developing chiral ligands or organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	(3R)-4-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Thiomorpholine-3-Carboxylic Acid
CAS No.	959572-96-4
Molecular Formula	C20H19NO5S
Molecular Weight	385.43 g/mol
Synonyms	Fmoc-(R)-3-Thiomorpholinecarboxylic Acid; (R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)thiomorpholine-3-carboxylic acid; (3R)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]thiomorpholine-3-carboxylic acid; (R)-N-Fmoc-thiomorpholine-3-carboxylic acid; Fmoc-Thiomorpholine-3-COOH (R-isomer); Thiomorpholine-3-carboxylic acid, 4-[(9H-fluoren-9-ylmethoxy)carbonyl]-, (3R)-; 959572-96-4; (R)-Fmoc-thiomorpholine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (3R)-4-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Thiomorpholine-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity suitable for research and pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.