Description

Methyl 2-Acetylamino-3-(2,5-Difluorophenyl)Acrylate is a high-value, specialized acrylate ester derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its molecular architecture, featuring both an acrylate moiety and a difluorophenyl group, makes it a versatile building block for constructing complex molecules with targeted properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Agrochemical Research: Building block for developing new-generation herbicides, fungicides, or insecticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Material Science Monomer: Used in research for creating specialty polymers with unique surface properties, adhesion, or chemical resistance due to the fluorinated aromatic group.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes and tags for studying biological processes and protein interactions.
• Liquid Crystal & OLED Material Development: Intermediate for synthesizing advanced organic electronic materials where the conjugated system and fluorine substitution are advantageous.

Basic Information

Product Name	Methyl 2-Acetylamino-3-(2,5-Difluorophenyl)Acrylate
CAS No.	959246-87-8
Molecular Formula	C₁₂H₁₁F₂NO₃
Molecular Weight	255.22 g/mol
Synonyms	Methyl (2E)-2-(acetylamino)-3-(2,5-difluorophenyl)-2-propenoate; (E)-Methyl 2-acetamido-3-(2,5-difluorophenyl)acrylate; 2-Propenoic acid, 2-(acetylamino)-3-(2,5-difluorophenyl)-, methyl ester, (2E)-; Methyl 2-acetamido-3-(2,5-difluorophenyl)acrylate; 959246-87-8; 2-Acetylamino-3-(2,5-difluorophenyl)acrylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Acetylamino-3-(2,5-Difluorophenyl)Acrylate adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP-compliant research and development activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.