Description

L-Cyclobutylglycine is a non-proteinogenic amino acid derivative featuring a cyclobutyl side chain, serving as a critical chiral building block in advanced organic synthesis. Its unique constrained ring structure makes it a valuable scaffold for modulating the conformational and physicochemical properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and neurological targets.
• Peptide Drug Design: Used to incorporate conformational constraints into peptide sequences, enhancing stability, potency, and selectivity.
• Protease & Enzyme Inhibitors: Serves as a core structure in designing potent and selective inhibitors for various enzymes.
• Chemical Biology & Proteomics: Employed as a tool compound or a labeled analog for studying protein function and interactions.
• Agrochemical Research: Utilized in the synthesis of novel compounds with potential herbicidal or pesticidal activity.
• Material Science: Acts as a monomer or precursor for specialized polymers and dendrimers with unique properties.

Basic Information

Product Name	L-Cyclobutylglycine
CAS No.	958788-10-8
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(S)-2-Amino-2-cyclobutylacetic acid; (S)-2-Cyclobutylglycine; L-2-Cyclobutylglycine; (S)-Aminocyclobutylacetic acid; Cyclobutylglycine, L-; H-Cyc(Bu)-OH; (2S)-2-Amino-2-cyclobutylacetic acid; (S)-(+)-2-Amino-2-cyclobutylacetic acid
EINECS	Contact for details

Quality Control

Our L-Cyclobutylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with major pharmacopeial and regulatory frameworks, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.