Description

(S)-1,4-Di-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is a high-purity, chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially protease inhibitors and receptor modulators.
• Peptidomimetics Research: Used to incorporate constrained piperazine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex chiral architectures.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis: Serves as a foundational piece for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Item	Detail
Product Name	(S)-1,4-Di-Boc-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	958635-19-3
Molecular Formula	C17H30N2O6
Molecular Weight	358.43 g/mol
Synonyms	(S)-Methyl 1,4-bis(tert-butoxycarbonyl)-2-piperazinecarboxylate; (S)-1,4-Di-tert-butoxycarbonyl-2-piperazinecarboxylic Acid Methyl Ester; (S)-1-Boc-4-Boc-piperazine-2-carboxylic Acid Methyl Ester; (S)-2-Methoxycarbonyl-1,4-diboc-piperazine; (S)-1,4-Di-Boc-piperazine-2-carboxylic Acid Methyl Ester; Methyl (S)-1,4-Di-Boc-piperazine-2-carboxylate; (S)-1,4-Bis(Boc)-piperazine-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (S)-1,4-Di-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if possible to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.