Description

4-Chloro-5-(trifluoromethyl)pyrimidine is a high-value halogenated pyrimidine building block, distinguished by its reactive chloro and trifluoromethyl substituents. This compound is essential for the synthesis of complex molecules, offering a versatile scaffold for introducing key functional groups in advanced chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine core.
• Material Science Research: Serves as a precursor for the development of advanced organic materials, including liquid crystals and electronic chemicals.
• Cross-Coupling Reactions: The chloro group is an effective handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form carbon-carbon and carbon-heteroatom bonds.
• Nucleophilic Substitution: Acts as an electrophile in nucleophilic aromatic substitution reactions, allowing for the introduction of amines, alkoxides, and other nucleophiles.
• Fluorine Chemistry: The trifluoromethyl group provides a metabolically stable and lipophilic moiety, making it valuable in medicinal chemistry for optimizing drug-like properties.

Basic Information

Product Name	4-Chloro-5-(trifluoromethyl)pyrimidine
CAS No.	958452-21-6
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	4-Chloro-5-(trifluoromethyl)pyrimidine; 5-(Trifluoromethyl)-4-chloropyrimidine; 4-Chloro-5-trifluoromethylpyrimidine; Pyrimidine, 4-chloro-5-(trifluoromethyl)-; 958452-21-6; 4-Chloro-5-trifluoromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-(trifluoromethyl)pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.