Description

Fmoc-Glu(OtBu)-Thr(PSiMe,Mepro)-OH is a sophisticated, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides critical control over side-chain reactivity, enabling the efficient and high-fidelity construction of complex peptides and peptidomimetics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptide-based drugs, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated or manual synthesis of complex peptide sequences.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting various diseases.
• Peptidomimetic Design: Essential for creating modified peptide structures with enhanced stability, bioavailability, or biological activity.
• Bioconjugation and Labeling: Serves as a precursor for introducing specific functional groups or labels into peptides for diagnostic or research purposes.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Research: A valuable tool for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Fmoc-Glu(OtBu)-Thr(PSiMe,Mepro)-OH
CAS No.	957780-56-2
Molecular Formula	C₃₄H₄₈N₂O₉PSi
Molecular Weight	696.81 g/mol
Synonyms	Fmoc-Glu(OtBu)-Thr[PO(OSiMe3)(Mepro)]-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-glutamyl-O-[methyl(propan-2-yl)phosphonoyl]-L-threonine; Fmoc-Glu(OtBu)-Thr(PO(OSiMe3)(OiPr))-OH; Fmoc-Glu(OtBu)-Thr(Psi(Me, iPr))-OH; Fmoc-L-Glutamic acid 5-tert-butyl ester-L-threonine(O-[methyl(1-methylethoxy)phosphinyl]) peptide; Protected Fmoc-Glutamic acid-Threonine dipeptide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your research and development under quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.