Description

Ethyl (S)-3-(tert-Butyldimethylsiloxy)Glutarate is a high-value chiral intermediate featuring a protected hydroxyl group. This compound is critical for the stereoselective synthesis of complex pharmaceutical molecules, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily needed by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in advanced organic synthesis and process development.

Application

• Chiral Building Block for the synthesis of statin-class drugs and other cardiovascular therapeutics.
• Key Intermediate in the production of complex natural products and bioactive compounds requiring specific stereochemistry.
• Pharmaceutical Research for developing new chemical entities (NCEs) and exploring novel synthetic pathways.
• Process Chemistry for scaling up the manufacture of enantiomerically pure APIs.
• Asymmetric Synthesis reagent for constructing molecules with defined stereocenters in medicinal chemistry.
• Protecting Group Chemistry studies, utilizing the tert-butyldimethylsilyl (TBDMS) ether moiety.

Basic Information

Product Name	Ethyl (S)-3-(tert-Butyldimethylsiloxy)Glutarate
CAS No.	957509-27-2
Molecular Formula	C13H26O5Si
Molecular Weight	290.43 g/mol
Synonyms	(S)-Ethyl 3-((tert-butyldimethylsilyl)oxy)glutarate; (S)-3-[(tert-Butyldimethylsilyl)oxy]pentanedioic Acid Ethyl Ester; Ethyl (S)-3-[(tert-Butyldimethylsilyl)oxy]glutarate; (S)-Ethyl 3-(TBDMSO)glutarate; Glutaric acid, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester, (S)-; Ethyl (3S)-3-[(tert-butyldimethylsilyl)oxy]pentanedioate
EINECS	Contact for details

Quality Control

Our Ethyl (S)-3-(tert-Butyldimethylsiloxy)Glutarate is manufactured under strict quality management systems to ensure high chemical and enantiomeric purity suitable for pharmaceutical research and development. Each batch is characterized by advanced analytical techniques including HPLC, GC, and NMR. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.