Description

Methyl 4-Bromo-2-(Trifluoromethyl)Benzoate is a high-purity, multi-functional aromatic ester building block of significant importance in advanced organic synthesis. Its core value lies in the strategic combination of bromo and trifluoromethyl substituents, which are critical for modulating the electronic and steric properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on molecular conformation, metabolic stability, and lipophilicity in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for drug discovery campaigns.

Basic Information

Item	Details
Product Name	Methyl 4-Bromo-2-(Trifluoromethyl)Benzoate
CAS No.	957207-58-8
Molecular Formula	C9H6BrF3O2
Molecular Weight	283.04 g/mol
Synonyms	4-Bromo-2-(trifluoromethyl)benzoic acid methyl ester; Methyl 4-bromo-α,α,α-trifluoro-o-toluate; Benzoic acid, 4-bromo-2-(trifluoromethyl)-, methyl ester; 4-Bromo-2-trifluoromethylbenzoic acid methyl ester; Methyl 4-bromo-2-(trifluoromethyl)benzoate; 957207-58-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-2-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and adherence to REACH compliance guarantees a reliable supply for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.