Description

Nh2-Peg-Nh2 is a linear, bifunctional polyethylene glycol (PEG) derivative featuring primary amine (-NH2) groups at both termini. This structure is critical for its role as a versatile heterobifunctional linker and spacer in advanced bioconjugation and materials science. It is essential for researchers and manufacturers requiring a hydrophilic, flexible, and reactive bridge to modify surfaces, crosslink polymers, or functionalize biomolecules. Key industries that utilize this compound include pharmaceuticals, diagnostics, and nanotechnology.

Application

• Bioconjugation and Crosslinking: Serves as a hydrophilic spacer to link proteins, peptides, antibodies, or other biomolecules with other functional groups or solid supports.
• Polymer Chemistry: Acts as a difunctional initiator or monomer for synthesizing polyurethane, polyurea, and other amine-reactive block copolymers.
• Surface Functionalization: Used to create amine-reactive coatings on nanoparticles, quantum dots, and diagnostic assay plates for subsequent biomolecule immobilization.
• Drug Delivery Systems: Incorporated into dendrimers, micelles, and hydrogel networks to enhance solubility, biocompatibility, and provide sites for drug attachment.
• Diagnostic Reagents: Employed in the development of fluorescent probes, biosensors, and immunoassay components.
• Materials Science: A key building block for creating smart materials, hydrogels, and non-fouling surfaces.

Basic Information

Product Name	Nh2-Peg-Nh2
CAS No.	956496-54-1
Molecular Formula	C2n+4H4n+10N2On+1 (n=PEG repeat units)
Molecular Weight	Variable (dependent on PEG chain length, e.g., 1kDa, 2kDa, 3.4kDa, 5kDa, 10kDa, 20kDa)
Synonyms	α,ω-Bis(2-aminoethyl)polyethylene glycol; Diamino Polyethylene Glycol; PEG-diamine; Bis(2-aminoethyl) PEG; Poly(oxyethylene)-bis-amine; H2N-PEG-NH2; Jeffamine® EDR series (related); O,O'-Bis(2-aminoethyl)polyethylene glycol
EINECS	Contact for details

Quality Control

Our Nh2-Peg-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. Standard quality parameters include assay by NMR, polydispersity index (PDI) by GPC, and confirmation of amine end-group content. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under an inert atmosphere (argon or nitrogen), desiccant is recommended to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (GPC)	As per ordered grade (e.g., 2000 Da ± 5%)
Polydispersity Index (PDI)	≤ 1.05
Assay (Purity by NMR)	≥ 95%
Amine Value (Titration)	As per theoretical value for specified MW
Water Content (KF)	≤ 1.0%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.