Description

Alkyne-Pegn-Nh2 2K, 5K, 10K, 20K CAS NO 956348-61-1 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal alkyne group for click chemistry and a primary amine group for further conjugation. This compound is essential for creating stable, biocompatible crosslinks and functionalizing biomolecules, nanoparticles, and surfaces. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling precise and efficient modification of peptides, proteins, and polymers.

Application

• Bioconjugation and Linker Chemistry: Used as a heterobifunctional crosslinker to attach biomolecules (e.g., peptides, antibodies) to surfaces, nanoparticles, or other polymers via click chemistry and amine-reactive chemistries.
• Drug Delivery Systems: Functionalizes liposomes, micelles, and polymeric nanoparticles to enhance targeting, stability, and pharmacokinetic profiles of therapeutic agents.
• Surface Modification: Creates functional PEGylated coatings on medical devices, biosensors, and diagnostic platforms to improve biocompatibility and reduce non-specific binding.
• Hydrogel Formation: Serves as a key building block in the synthesis of PEG-based hydrogels for tissue engineering, 3D cell culture, and controlled release applications.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies, a core strategy in modern oncology therapeutics.
• Diagnostic Reagent Preparation: Used to label probes, dyes, and contrast agents for in vitro and in vivo imaging and detection.

Basic Information

Product Name	Alkyne-Pegn-Nh2 2K, 5K, 10K, 20K
CAS No.	956348-61-1
Molecular Formula	C2n+5H4n+11NOn+1 (n = PEG repeat units)
Molecular Weight	2,000 Da (2K), 5,000 Da (5K), 10,000 Da (10K), 20,000 Da (20K) (nominal)
Synonyms	Alkyne-PEG-Amine; Propargyl-PEG-Amine; NH2-PEG-Alkyne; α-Alkyne-ω-Amino Polyethylene Glycol; Amino-PEG-Propargyl; PEG-Alkyne-NH2; Propargyl-PEG-NH2; Heterobifunctional PEG Alkyne Amine
EINECS	Contact for details

Quality Control

Our Alkyne-Pegn-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, precise molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) are provided with each shipment, detailing specifications for purity (by NMR/HPLC), functional group substitution, polydispersity index (PDI), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Complies
Purity (HPLC)	≥ 95%
Molecular Weight (Nominal)	2K, 5K, 10K, 20K
Polydispersity Index (PDI)	≤ 1.05
Functional Group Substitution	≥ 90% (by end-group analysis)
Water Content (KF)	≤ 1.0%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.