Description

Diazepam Binding Inhibitor Fragment (Human) CAS NO 104360-70-5 is a synthetic peptide fragment corresponding to the biologically active region of the endogenous diazepam binding inhibitor (DBI) protein. This compound is a critical research tool for investigating the modulation of GABA-A receptors and the role of DBI in neurological processes. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical researchers focused on neuropharmacology, anxiety mechanisms, and receptor-ligand interactions.

Application

• Neuroscience Research: A key reagent for studying the function and regulation of central benzodiazepine receptors (CBR) and GABAergic neurotransmission.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel anxiolytics, anticonvulsants, or modulators of the GABA-A receptor complex.
• Biochemical Assays: Serves as a reference standard or competitive ligand in receptor binding studies, displacement assays, and functional activity tests.
• Mechanistic Studies: Facilitates research into the physiological and pathological roles of endozepines in stress response, anxiety, and seizure thresholds.
• Peptide Chemistry: Used as a building block or reference compound in peptide synthesis and structure-activity relationship (SAR) studies for neuroactive peptides.

Basic Information

Product Name	Diazepam Binding Inhibitor Fragment (Human)
CAS No.	104360-70-5
Molecular Formula	C41H68N12O11S
Molecular Weight	913.1 g/mol
Synonyms	DBI Fragment (Human); ODN (Octadecaneuropeptide); Diazepam Binding Inhibitor (17-50), human; DBI (17-50); Octadecaneuropeptide (ODN); QATVGDVNTDRPGLLDLK; Endozepine Fragment; GABAA Receptor Modulator Peptide
EINECS	Contact for details

Quality Control

Our Diazepam Binding Inhibitor Fragment (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure consistency and reliability for critical research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.