Description

Sulfosuccinimidyl-3-(4-Hydroxyphenyl)Propionate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a phenol group that can be further modified. This compound is essential for creating stable, site-specific conjugates between proteins, peptides, and other biomolecules, enabling advanced research and diagnostic assay development. It is a critical tool for scientists and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and immunoassay fabrication.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used to covalently attach cytotoxic drugs to monoclonal antibodies via the phenol moiety, enabling targeted cancer therapies.
• Protein and Peptide Labeling: Facilitates the site-specific introduction of fluorescent dyes, biotin, or other probes onto biomolecules for detection and imaging.
• Immunoassay Development: Employed in the preparation of enzyme-antibody or hapten-carrier protein conjugates for ELISA and other diagnostic platforms.
• Biomaterial and Surface Functionalization: Used to immobilize proteins or peptides onto solid supports (e.g., sensor chips, microplates, nanoparticles) while controlling orientation.
• Crosslinking for Structural Studies: Aids in studying protein-protein interactions and complex structures through the introduction of defined crosslinks.
• Oligonucleotide Conjugation: Enables the attachment of proteins or other ligands to oligonucleotides for applications in targeted delivery and molecular diagnostics.

Basic Information

Product Name	Sulfosuccinimidyl-3-(4-Hydroxyphenyl)Propionate
CAS No.	106327-86-0
Molecular Formula	C13H11NO7S
Molecular Weight	325.29 g/mol
Synonyms	3-(4-Hydroxyphenyl)propionic acid N-sulfosuccinimidyl ester; Sulfo-SHPP; N-Hydroxysulfosuccinimide ester of 3-(4-hydroxyphenyl)propionic acid; 4-Hydroxyphenylpropionic acid sulfo-NHS ester; 3-(4-Hydroxyphenyl)propionyloxysulfosuccinimide; Sulfo-NHS ester of HPPA; NHS-PEG3-Phenol (related); Water-soluble NHS-Phenol crosslinker
EINECS	Contact for details

Quality Control

Our Sulfosuccinimidyl-3-(4-Hydroxyphenyl)Propionate is manufactured under strict quality systems to ensure batch-to-batch consistency and high reactivity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research, development, and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.