Description

Hemoglobin S-Antilles CAS NO 107720-98-9 is a specific variant of hemoglobin, a critical oxygen-transporting protein in red blood cells, characterized by a double mutation (β6 Glu→Val and β23 Val→Ile) that significantly impacts its polymerization behavior. This compound is of paramount importance for biomedical research, particularly in the study of sickle cell disease pathophysiology and the development of targeted therapeutic strategies. It is an essential biochemical reagent for pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions focused on hematology and genetic disorders.

Application

• Biomedical Research: Fundamental studies on hemoglobin polymerization kinetics, sickling mechanisms, and red blood cell rheology in sickle cell disease models.
• Pharmaceutical Development: Serving as a key reference standard and target molecule in the screening and validation of novel anti-sickling agents and gene therapies.
• Diagnostic Assays: Utilization as a calibrated control or challenge material in the development and quality control of diagnostic tests for hemoglobinopathies.
• Biophysical Studies: Investigation of protein-protein interactions, oxygen affinity, and allosteric regulation using advanced spectroscopic and crystallographic techniques.
• Educational & Reference Material: Used in advanced university courses and professional training programs in biochemistry, molecular medicine, and clinical laboratory science.

Basic Information

Product Name	Hemoglobin S-Antilles
CAS No.	107720-98-9
Molecular Formula	C2952H4664N812O840S16Fe4 (Human hemoglobin β chain variant)
Molecular Weight	~64,500 Da (Tetramer)
Synonyms	Hb S-Antilles; Hemoglobin S Antilles; Double Mutant Hemoglobin S-Antilles; β6(A3)Glu→Val, β23(B5)Val→Ile Hemoglobin; Deoxyhemoglobin S-Antilles; Sickle Hemoglobin Antilles Variant; HBB p.Glu6Val AND p.Val23Ile; Hemoglobin β-Globin Chain Mutant
EINECS	Contact for details

Quality Control

Our Hemoglobin S-Antilles is produced and handled under stringent conditions to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is subjected to comprehensive analytical characterization, including purity assessment, functional activity testing, and verification of the specific mutation profile. A Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), methemoglobin content, electrophoresis profile, and oxygen-binding characteristics is provided with every shipment, supporting compliance with rigorous laboratory standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccated conditions after each use. Handle using appropriate procedures for handling proteins and biochemicals.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Electrophoresis)	Consistent with Hemoglobin S-Antilles profile
Purity (HPLC)	≥ 95% (Main peak)
Methemoglobin Content	< 5%
Protein Concentration	As per COA
Solvent/Buffer	Specified per grade (e.g., Phosphate Buffer)
Biological Activity (O2 affinity)	Reported (P50 value)
Endotoxin Level	< 1.0 EU/mg (for cell culture grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.