Description

(6-(4-Benzamido-2-Oxopyrimidin-1(2H)-Yl)-4-Tritylmorpholin-2-Yl)Methyl Dimethylphosphoramidochloridate is a sophisticated phosphoramidite monomer, a critical building block in the chemical synthesis of complex molecules. Its value lies in its role as a key intermediate for the production of nucleoside analogs and oligonucleotides, enabling precise control over molecular architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel therapeutics, diagnostic probes, and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Serves as a protected phosphoramidite monomer for solid-phase synthesis of DNA and RNA oligonucleotides for research, diagnostics, and therapeutic applications.
• Prodrug Development: Used in the design and synthesis of prodrugs to enhance the bioavailability and targeted delivery of nucleotide analogs.
• Chemical Biology Research: Enables the site-specific incorporation of modified nucleotides into nucleic acids to study biological processes and mechanisms.
• Antisense & siRNA Therapeutics: A key raw material in the manufacturing of antisense oligonucleotides and small interfering RNA (siRNA) candidates for gene silencing therapies.
• Process Development & Scale-Up: Supports process chemistry teams in optimizing synthetic routes from laboratory to pilot and commercial scale production.

Basic Information

Item	Detail
Product Name	(6-(4-Benzamido-2-Oxopyrimidin-1(2H)-Yl)-4-Tritylmorpholin-2-Yl)Methyl Dimethylphosphoramidochloridate
CAS No.	956139-21-2
Molecular Formula	C45H44ClN4O5P
Molecular Weight	811.27 g/mol
Synonyms	4-[(6-{4-[(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-trityl-2-morpholinyl}methyl]-N,N-dimethylphosphoramidic chloride; Protected Nucleoside Phosphoramidite; Morpholino Phosphoramidochloridate Intermediate; Trityl-protected Morpholino Monomer; Benzamido-oxopyrimidinyl Morpholine Phosphoramidite
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, NMR (¹H, ³¹P, ¹³C), and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (³¹P NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, DCM, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.