Description

1-tert-Butyl-3-(Naphthalen-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Hydrochloride CAS NO 956025-47-1 is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of active pharmaceutical ingredients (APIs) for targeted cancer therapies.
• Kinase Inhibitor Research: Serves as a core scaffold in medicinal chemistry programs focused on designing and optimizing potent kinase inhibitors.
• Biochemical Research: Used as a reference standard or tool compound in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Process Development & Scale-up: Employed in process chemistry for route scouting, optimization, and the commercial-scale manufacturing of complex drug molecules.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacology studies.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	1-tert-Butyl-3-(Naphthalen-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Hydrochloride
CAS No.	956025-47-1
Molecular Formula	C23H24ClN5
Molecular Weight	405.92 g/mol
Synonyms	1-(tert-Butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride; 1-tert-Butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine HCl; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-, hydrochloride (1:1); NVP-BEZ235 Intermediate; Dactolisib Intermediate; BEZ235 Intermediate; Pyrazolopyrimidine Derivative
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl-3-(Naphthalen-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Hydrochloride adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Specifications can be tailored to meet research-grade or cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.